[1] Novak Djokovič 7-5,6-3 John Isner [17] 2019-10-10 07:00
Stadium: Center Court 1 Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP - World Tour Finals | 2018/11/12 20:00 | Novak Djokovič v John Isner | 6-4,6-3 |
| ATP - Miami | 2015/04/03 23:00 | Novak Djokovič v John Isner | 7-6,6-2 |
Home History
| ATP - Šanghaj | 2019/10/09 10:30 | Novak Djokovič v Denis Shapovalov | 6-3,6-3 |
| ATP - Tokio | 2019/10/06 06:30 | Novak Djokovič v John Millman | 6-3,6-2 |
| ATP - Tokio | 2019/10/05 06:00 | Novak Djokovič v David Goffin | 6-3,6-4 |
| ATP - Tokio | 2019/10/04 05:15 | Novak Djokovič v Lucas Pouille | 6-1,6-2 |
| ATP - Tokio | 2019/10/02 07:20 | Novak Djokovič v Go Soeda | 6-3,7-5 |
| ATP - Tokio | 2019/10/01 06:10 | Novak Djokovič v Alexei Popyrin | 6-4,6-2 |
| US Open | 2019/08/31 00:45 | Novak Djokovič v Denis Kudla | 6-3,6-4,6-2 |
| US Open | 2019/08/28 23:00 | Novak Djokovič v Juan Ignacio Londero | 6-4,7-6,6-1 |
Away History
| ATP - Šanghaj | 2019/10/09 04:30 | Lucas Pouille v John Isner | 5-7,3-6 |
| ATP - Šanghaj | 2019/10/08 04:30 | Alex De Minaur v John Isner | 6-7,4-6 |
| ATP - Peking | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| ATP - Peking | 2019/10/03 06:30 | John Isner v Daniel Evans | 7-6,7-5 |
| ATP - Peking | 2019/10/01 05:00 | Gael Monfils v John Isner | 4-6,7-6,3-6 |
| ATP - Chengdu | 2019/09/26 09:30 | John Isner v Egor Gerasimov | 7-6,6-7,6-7 |
| Laver Cup | 2019/09/22 14:45 | Roger Federer v John Isner | 6-4,7-6 |
| Laver Cup | 2019/09/21 11:00 | Alexander Zverev v John Isner | 7-6,4-6,1-10 |