Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Rob Tenyer
| NCAAF | 2021/04/17 20:00 | Butler v Morehead State | W | 18-28 |
| NCAAF | 2021/04/10 16:00 | Valparaiso v Morehead State | W | 24-28 |
| NCAAF | 2021/04/03 19:00 | Morehead State v Butler | W | 35-14 |
| NCAAF | 2021/03/27 16:00 | Morehead State v Davidson Wildcats | L | 21-24 |
| NCAAF | 2021/03/20 16:00 | Stetson Hatters v Morehead State | W | 14-31 |
| NCAAF | 2021/03/13 17:00 | Morehead State v Presbyterian | L | 16-31 |
| NCAAF | 2021/02/20 17:00 | Morehead State v James Madison | L | 0-52 |
| NCAAF | 2019/11/23 18:00 | Stetson Hatters v Morehead State | L | 31-16 |
| NCAAF | 2021/05/08 18:30 | James Madison v Sam Houston State | L | 35-38 |
| NCAAF | 2021/05/02 22:00 | North Dakota v James Madison | W | 21-34 |
| NCAAF | 2021/04/24 18:00 | VMI v James Madison | W | 24-31 |
| NCAAF | 2021/04/17 18:00 | Richmond v James Madison | W | 6-23 |
| NCAAF | 2021/03/27 17:00 | James Madison v William & Mary | W | 38-10 |
| NCAAF | 2021/03/06 18:30 | James Madison v Elon | W | 20-17 |
| NCAAF | 2021/02/27 17:00 | Robert Morris v James Madison | W | 16-36 |
| NCAAF | 2021/02/20 17:00 | Morehead State v James Madison | W | 0-52 |