[10] Santos Laguna 1-2 Monterrey [4] 2021-09-27 00:06
Stadium: Estadio TSM Corona Round: 10
Referee: Marco Antonio Ortiz Nava Home Manager: Guillermo Almada Away Manager: Javier Aguirre
Head to Head
| Mexiko - Liga MX | 2021/05/16 23:00 | Monterrey v Santos Laguna | D | 1-1 |
| Mexiko - Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | W | 2-1 |
| Mexiko - Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | W | 1-0 |
| Mexiko - Liga MX | 2020/08/09 00:06 | Monterrey v Santos Laguna | D | 2-2 |
| Mexický pohár | 2020/02/20 01:00 | Monterrey v Santos Laguna | L | 1-0 |
| Mexický pohár | 2020/02/12 01:00 | Santos Laguna v Monterrey | D | 0-0 |
| Mexiko - Liga MX | 2019/12/02 01:00 | Santos Laguna v Monterrey | D | 1-1 |
| Mexiko - Liga MX | 2019/11/29 01:06 | Monterrey v Santos Laguna | L | 5-2 |
Home History
| Mexiko - Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |
| Mexiko - Liga MX | 2021/08/29 23:00 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexiko - Liga MX | 2021/08/22 00:00 | Leon v Santos Laguna | D | 1-1 |
| Mexiko - Liga MX | 2021/08/19 00:00 | Santos Laguna v Atlas | D | 1-1 |
| Mexiko - Liga MX | 2021/08/16 00:06 | Santos Laguna v Chivas Guadalajara | D | 0-0 |
| Leagues Cup | 2021/08/12 23:00 | Orlando City SC v Santos Laguna | W | 0-1 |
Away History
| Mexiko - Liga MX | 2021/09/23 00:06 | Monterrey v Toluca | W | 2-0 |
| Mexiko - Liga MX | 2021/09/20 00:06 | Monterrey v Tigres UANL | W | 2-0 |
| Pohár majstrov CONCACAF | 2021/09/17 02:00 | Cruz Azul v Monterrey | W | 1-4 |
| Mexiko - Liga MX | 2021/09/11 22:00 | Atlas v Monterrey | L | 2-1 |
| Mexiko - Liga MX | 2021/08/28 02:05 | Tijuana v Monterrey | D | 2-2 |
| Mexiko - Liga MX | 2021/08/22 02:36 | Monterrey v Chivas Guadalajara | D | 0-0 |
| Mexiko - Liga MX | 2021/08/19 00:00 | Cruz Azul v Monterrey | D | 1-1 |
| Mexiko - Liga MX | 2021/08/15 02:06 | Monterrey v Pachuca | W | 3-1 |