Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Jason Simpson
| NCAAF | 2021/03/07 19:00 | Eastern Illinois v Tennessee Martin | W | 15-28 |
| NCAAF | 2019/10/19 19:00 | Eastern Illinois v Tennessee Martin | W | 18-27 |
| NCAAF | 2018/10/20 19:00 | Eastern Illinois v Tennessee Martin | L | 24-21 |
| NCAAF | 2017/10/28 19:00 | Tennessee Martin v Eastern Illinois | W | 27-10 |
| NCAAF | 2021/10/09 19:00 | Murray State v Tennessee Martin | W | 24-48 |
| NCAAF | 2021/09/25 20:00 | Tennessee Martin v Jacksonville State | W | 34-31 |
| NCAAF | 2021/09/18 23:00 | Tennessee Martin v Northwestern State | W | 35-10 |
| NCAAF | 2021/09/11 23:00 | Samford v Tennessee Martin | W | 27-33 |
| NCAAF | 2021/09/03 00:00 | Tennessee Martin v Western Kentucky | L | 21-59 |
| NCAAF | 2021/04/11 20:00 | Tennessee Tech v Tennessee Martin | W | 7-40 |
| NCAAF | 2021/04/03 18:00 | SE Missouri St v Tennessee Martin | L | 21-16 |
| NCAAF | 2021/03/28 19:00 | Tennessee Martin v Tennessee State | L | 24-26 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | L | 0-46 |
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |