[2] Penarol 0-0 Nacional De Football [5] 2021-10-31 19:00
Stadium: Estadio Campeon del Siglo Round: 9
Referee: Andres Matonte Home Manager: Mauricio Larriera Away Manager: Martin Ricardo Liguera Lopez
Head to Head
| Copa Sudamericana | 2021/07/23 00:30 | Penarol v Nacional De Football | L | 0-1 |
| Copa Sudamericana | 2021/07/16 00:30 | Nacional De Football v Penarol | W | 1-2 |
| Uruguaj - Apertura | 2021/07/04 19:00 | Nacional De Football v Penarol | L | 2-0 |
| Uruguaj - Clausura | 2021/02/03 21:30 | Penarol v Nacional De Football | D | 0-0 |
| Uruguaj - Torneo Intermedio | 2020/12/13 20:30 | Penarol v Nacional De Football | W | 3-2 |
| Uruguaj - Apertura | 2020/08/09 18:00 | Nacional De Football v Penarol | D | 1-1 |
| Uruguaj - Grand Final | 2019/12/15 20:00 | Nacional De Football v Penarol | L | 1-0 |
| Uruguaj - Grand Final | 2019/12/11 23:30 | Penarol v Nacional De Football | L | 0-2 |
Home History
| Uruguaj - Clausura | 2021/10/23 22:00 | Villa Espanola v Penarol | W | 1-3 |
| Uruguaj - Clausura | 2021/10/20 23:30 | Penarol v Torque | W | 3-1 |
| Uruguaj - Clausura | 2021/10/17 18:30 | Deportivo Maldonado v Penarol | L | 1-0 |
| Uruguaj - Clausura | 2021/10/09 18:30 | Rentistas v Penarol | W | 0-1 |
| Uruguaj - Clausura | 2021/10/04 00:00 | Penarol v Montevideo Wanderers | W | 3-0 |
| Copa Sudamericana | 2021/10/01 00:30 | Athletico Paranaense v Penarol | L | 2-0 |
| Uruguaj - Clausura | 2021/09/26 18:30 | Boston River v Penarol | W | 2-5 |
| Copa Sudamericana | 2021/09/24 00:30 | Penarol v Athletico Paranaense | L | 1-2 |
Away History
| Uruguaj - Clausura | 2021/10/24 23:30 | Nacional De Football v Rentistas | D | 2-2 |
| Uruguaj - Clausura | 2021/10/21 23:30 | Montevideo Wanderers v Nacional De Football | L | 1-0 |
| Uruguaj - Clausura | 2021/10/16 21:00 | Nacional De Football v Boston River | W | 3-2 |
| Uruguaj - Clausura | 2021/10/10 17:45 | Atletico Fenix Montevideo v Nacional De Football | W | 1-2 |
| Uruguaj - Clausura | 2021/10/03 18:30 | Nacional De Football v Plaza Colonia | W | 2-1 |
| Uruguaj - Clausura | 2021/09/25 21:30 | IA Sud America v Nacional De Football | W | 0-2 |
| Uruguaj - Clausura | 2021/09/19 18:30 | Nacional De Football v Club Atletico Progreso | L | 0-1 |
| Uruguaj - Clausura | 2021/09/11 21:30 | Cerro Largo v Nacional De Football | D | 1-1 |