[26] Louisville 28-31 Air Force [21] 2021-12-28 20:15
Stadium: Gerald J. Ford Stadium Round: 326
Home Manager: Scott Satterfield Away Manager: Troy Calhoun
Home History
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virgínia v Louisville | L | 34-33 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | L | 34-37 |
Away History
| NCAAF | 2021/11/26 20:30 | UNLV v Air Force | W | 14-48 |
| NCAAF | 2021/11/20 02:00 | Air Force v Nevada | W | 41-39 |
| NCAAF | 2021/11/14 00:00 | Air Force v Colorado State | W | 35-21 |
| NCAAF | 2021/11/06 15:30 | Army v Air Force | L | 21-14 |
| NCAAF | 2021/10/23 23:00 | San Diego State v Air Force | L | 20-14 |
| NCAAF | 2021/10/17 01:00 | Air Force v Boise State | W | 24-17 |
| NCAAF | 2021/10/09 23:00 | Wyoming v Air Force | W | 14-24 |
| NCAAF | 2021/10/02 22:30 | Air Force v Nové Mexiko | W | 38-10 |