[6] BUF Sabres 3-4 FLA Panthers [1] 2022-04-08 23:00
Stadium: Amerant Bank Arena
Home Manager: Andrew Brunette Away Manager: Don Granato
Head to Head
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/03/08 00:00 | FLA Panthers v BUF Sabres | L | 6-1 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2020/01/04 18:00 | FLA Panthers v BUF Sabres | W | 2-3 |
| NHL | 2019/11/24 22:00 | BUF Sabres v FLA Panthers | W | 5-2 |
| NHL | 2019/10/11 23:00 | FLA Panthers v BUF Sabres | W | 2-3 |
| NHL | 2019/02/20 00:00 | BUF Sabres v FLA Panthers | L | 2-4 |
| NHL | 2019/01/04 00:00 | FLA Panthers v BUF Sabres | W | 3-4 |
Home History
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/04/05 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |
| NHL | 2022/03/30 23:00 | WIN Jets v BUF Sabres | L | 3-2 |
| NHL | 2022/03/29 00:30 | BUF Sabres v CHI Blackhawks | W | 6-5 |
| NHL | 2022/03/27 21:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2022/03/25 23:00 | WAS Capitals v BUF Sabres | L | 4-3 |
Away History
| NHL | 2022/04/05 23:00 | TOR Maple Leafs v FLA Panthers | W | 6-7 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | W | 5-3 |
| NHL | 2022/04/02 16:30 | FLA Panthers v NJ Devils | W | 7-6 |
| NHL | 2022/03/31 23:00 | CHI Blackhawks v FLA Panthers | W | 0-4 |
| NHL | 2022/03/29 23:00 | MON Canadiens v FLA Panthers | W | 4-7 |
| NHL | 2022/03/27 23:00 | FLA Panthers v TOR Maple Leafs | L | 2-5 |
| NHL | 2022/03/26 23:00 | FLA Panthers v OTT Senators | W | 4-3 |
| NHL | 2022/03/24 23:00 | FLA Panthers v MON Canadiens | W | 4-3 |