[5] London Irish 37-22 Northampton [4] 2023-03-25 17:30
Stadium: Brentford Community Stadium Round: 21
Referee: Anthony Woodthorpe Home Manager: Declan Kidney Away Manager: Chris Boyd
Head to Head
| Premiership Rugby Cup | 2023/02/10 19:45 | London Irish v Northampton | W | 30-18 |
| Premiership Rugby Cup | 2022/09/27 18:45 | London Irish v Northampton | W | 28-26 |
| Premiership Rugby | 2022/09/17 13:00 | Northampton v London Irish | L | 38-22 |
| Premiership Rugby | 2022/03/26 15:00 | London Irish v Northampton | L | 22-42 |
| Premiership Rugby Cup | 2021/11/13 15:30 | Northampton v London Irish | W | 26-36 |
| Premiership Rugby | 2021/10/02 13:00 | Northampton v London Irish | L | 23-21 |
| Premiership Rugby | 2021/04/16 18:45 | Northampton v London Irish | L | 44-26 |
| Premiership Rugby | 2020/08/22 13:00 | London Irish v Northampton | L | 3-27 |
Home History
| Premiership Rugby Cup | 2023/03/19 14:00 | London Irish v Exeter Chiefs | L | 20-24 |
| Premiership Rugby | 2023/03/12 13:00 | London Irish v Sale Sharks | W | 36-18 |
| Premiership Rugby | 2023/03/05 15:00 | Newcastle Falcons v London Irish | W | 19-34 |
| Premiership Rugby | 2023/02/25 19:30 | London Irish v Leicester | L | 22-25 |
| Premiership Rugby | 2023/02/18 15:00 | Bath v London Irish | W | 10-25 |
| Premiership Rugby Cup | 2023/02/10 19:45 | London Irish v Northampton | W | 30-18 |
| Premiership Rugby | 2023/01/29 15:00 | London Irish v Harlequins | W | 42-24 |
| European Rugby Champions Cup | 2023/01/22 13:00 | Montpellier v London Irish | D | 21-21 |
Away History
| Premiership Rugby | 2023/03/10 19:45 | Northampton v Bath | W | 45-26 |
| Premiership Rugby | 2023/03/03 19:45 | Bristol v Northampton | L | 62-8 |
| Premiership Rugby | 2023/02/25 14:45 | Northampton v Gloucester | W | 41-34 |
| Premiership Rugby | 2023/02/18 15:00 | Northampton v Sale Sharks | W | 38-34 |
| Premiership Rugby Cup | 2023/02/10 19:45 | London Irish v Northampton | L | 30-18 |
| Premiership Rugby | 2023/01/28 14:00 | Leicester v Northampton | W | 18-19 |
| European Rugby Champions Cup | 2023/01/21 13:00 | Northampton v La Rochelle | L | 13-31 |
| European Rugby Champions Cup | 2023/01/14 15:15 | Munster v Northampton | L | 27-23 |