Stadium: Cooper Field Round: 1
Home Manager: Rob Sgarlata Away Manager: Ray Priore
| NCAAF | 2022/09/30 23:00 | Pennsylvania v Dartmouth | W | 23-17 |
| NCAAF | 2022/09/24 17:00 | Lafayette v Pennsylvania | W | 0-12 |
| NCAAF | 2022/09/17 17:00 | Colgate v Pennsylvania | W | 14-25 |
| NCAAF | 2021/11/20 18:00 | Princeton v Pennsylvania | L | 34-14 |
| NCAAF | 2021/11/13 17:00 | Pennsylvania v Harvard | L | 7-23 |
| NCAAF | 2021/11/06 17:00 | Cornell Big Red v Pennsylvania | L | 15-12 |
| NCAAF | 2021/10/30 17:00 | Brown v Pennsylvania | W | 17-45 |
| NCAAF | 2021/10/23 16:00 | Pennsylvania v Yale | L | 28-42 |
| NCAAF | 2022/10/01 17:00 | Georgetown v Fordham | L | 38-59 |
| NCAAF | 2022/09/24 16:30 | Columbia v Georgetown | L | 42-6 |
| NCAAF | 2022/09/17 17:00 | Georgetown v Monmouth | L | 6-45 |
| NCAAF | 2022/09/10 21:00 | Lehigh v Georgetown | L | 21-19 |
| NCAAF | 2022/09/03 16:00 | Georgetown v Marist | W | 43-12 |
| NCAAF | 2021/11/20 17:00 | Georgetown v Morgan State | L | 21-28 |
| NCAAF | 2021/11/13 17:00 | Georgetown v Lehigh | L | 9-23 |
| NCAAF | 2021/11/06 16:30 | Fordham v Georgetown | L | 41-20 |