Stadium: Independence Stadium Round: 344
Home Manager: Dana Holgorsen Away Manager: Michael Desormeaux
| NCAAF | 2006/10/07 12:00 | Houston v Lafayette | L | 28-31 |
| NCAAF | 2003/09/13 12:00 | Lafayette v Houston | W | 14-21 |
| NCAAF | 2002/09/14 12:00 | Houston v Lafayette | W | 36-17 |
| NCAAF | 2022/11/27 00:30 | Tulsa v Houston | L | 37-30 |
| NCAAF | 2022/11/19 19:00 | Houston v East Carolina | W | 42-3 |
| NCAAF | 2022/11/12 20:00 | Temple v Houston | W | 36-43 |
| NCAAF | 2022/11/05 23:00 | Houston v SMU | L | 63-77 |
| NCAAF | 2022/10/29 16:00 | South Florida v Houston | W | 27-42 |
| NCAAF | 2022/10/22 16:00 | Houston v Navy | W | 38-20 |
| NCAAF | 2022/10/08 12:28 | Houston v Tulane | D | 0-0 |
| NCAAF | 2022/10/07 23:30 | Houston v Memphis | W | 33-32 |
| NCAAF | 2022/11/26 22:00 | Lafayette v Texas State | W | 41-13 |
| NCAAF | 2022/11/19 17:30 | Lehigh v Lafayette | W | 11-14 |
| NCAAF | 2022/11/19 17:00 | Lafayette v Florida State | L | 17-49 |
| NCAAF | 2022/11/12 18:00 | Lafayette v Fordham | L | 10-45 |
| NCAAF | 2022/11/11 00:30 | Georgia Southern v Lafayette | W | 17-36 |
| NCAAF | 2022/11/05 21:00 | Troy v Lafayette | L | 23-17 |
| NCAAF | 2022/11/05 17:00 | Lafayette v Colgate | W | 21-16 |
| NCAAF | 2022/10/29 16:30 | Georgetown v Lafayette | L | 30-20 |