Stadium: Glover Stadium Round: 1
| NCAAF | 2022/08/27 20:00 | Florida Memorial University Lions v Edward Waters Tigers | L | 39-34 |
| NCAAF | 2022/11/12 23:00 | Edward Waters Tigers v Allen Yellow Jackets | W | 38-12 |
| NCAAF | 2022/10/27 23:00 | Miles Golden Bears v Edward Waters Tigers | W | 16-22 |
| NCAAF | 2022/10/22 17:00 | Central State v Edward Waters Tigers | W | 13-45 |
| NCAAF | 2022/10/15 17:00 | North Carolina A&T v Edward Waters Tigers | L | 45-7 |
| NCAAF | 2022/10/08 22:00 | Edward Waters Tigers v Albany State Golden Rams | L | 7-55 |
| NCAAF | 2022/10/02 18:00 | Edward Waters Tigers v Morehouse College Maroon Tigers | W | 49-20 |
| NCAAF | 2022/09/24 19:00 | Lane College Dragons v Edward Waters Tigers | L | 20-9 |
| NCAAF | 2022/09/10 22:00 | Edward Waters Tigers v Savannah State | L | 28-31 |