[2] Cincinnati 35-13 East Carolina [42] 2021-11-26 20:30
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Mike Houston Away Manager: Luke Fickell
Head to Head
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | W | 17-55 |
| NCAAF | 2019/11/02 23:00 | Cincinnati v East Carolina | W | 46-43 |
| NCAAF | 2018/11/23 20:30 | East Carolina v Cincinnati | W | 6-56 |
| NCAAF | 2017/11/18 17:00 | Cincinnati v East Carolina | L | 20-48 |
| NCAAF | 2016/10/22 23:00 | East Carolina v Cincinnati | W | 19-31 |
| NCAAF | 2015/11/28 17:00 | East Carolina v Cincinnati | W | 16-19 |
| NCAAF | 2014/11/14 00:00 | Cincinnati v East Carolina | W | 54-46 |
| NCAAF | 2004/09/25 12:00 | East Carolina v Cincinnati | W | 19-24 |
| NCAAF | 2003/09/01 12:00 | Cincinnati v East Carolina | W | 40-3 |
| NCAAF | 2002/12/06 12:00 | East Carolina v Cincinnati | W | 26-42 |
| NCAAF | 2001/11/10 12:00 | Cincinnati v East Carolina | L | 26-28 |