[5] Cruz Azul 0-1 Atletico San Luis [10] 2022-04-24 22:00
Stadium: Estadio Azteca Round: 16
Referee: Jesus Rafael Lopez Valle Home Manager: Juan Reynoso Away Manager: Andre Jardine
Head to Head
| Mexiko - Liga MX | 2021/08/22 02:00 | Atletico San Luis v Cruz Azul | D | 0-0 |
| Mexiko - Liga MX | 2021/04/24 22:00 | Cruz Azul v Atletico San Luis | W | 3-2 |
| Mexiko - Liga MX | 2020/08/24 00:35 | Atletico San Luis v Cruz Azul | W | 1-3 |
| Mexiko - Liga MX | 2020/01/18 01:00 | Atletico San Luis v Cruz Azul | L | 2-1 |
| Mexiko - Liga MX | 2019/11/24 01:00 | Cruz Azul v Atletico San Luis | W | 3-1 |
Home History
| Mexiko - Liga MX | 2022/04/22 02:00 | Queretaro v Cruz Azul | W | 0-1 |
| Mexiko - Liga MX | 2022/04/17 02:00 | Cruz Azul v Chivas Guadalajara | L | 0-1 |
| Pohár majstrov CONCACAF | 2022/04/13 02:00 | Cruz Azul v Unam Pumas | D | 0-0 |
| Mexiko - Liga MX | 2022/04/09 02:00 | Mazatlan FC v Cruz Azul | D | 1-1 |
| Pohár majstrov CONCACAF | 2022/04/06 02:00 | Unam Pumas v Cruz Azul | L | 2-1 |
| Mexiko - Liga MX | 2022/04/02 23:00 | Cruz Azul v Atlas | W | 1-0 |
| Mexiko - Liga MX | 2022/03/20 03:00 | Pachuca v Cruz Azul | L | 1-0 |
| Pohár majstrov CONCACAF | 2022/03/17 00:00 | CF Montreal v Cruz Azul | D | 1-1 |
Away History
| Mexiko - Liga MX | 2022/04/21 00:00 | Atletico San Luis v Unam Pumas | W | 2-0 |
| Mexiko - Liga MX | 2022/04/16 00:00 | Necaxa v Atletico San Luis | L | 4-2 |
| Mexiko - Liga MX | 2022/04/09 22:00 | Atletico San Luis v Leon | W | 2-0 |
| Mexiko - Liga MX | 2022/04/07 02:06 | Tijuana v Atletico San Luis | D | 1-1 |
| Mexiko - Liga MX | 2022/04/02 02:00 | Atletico San Luis v Mazatlan FC | W | 1-0 |
| Mexiko - Liga MX | 2022/03/18 03:05 | Queretaro v Atletico San Luis | L | 2-1 |
| Mexiko - Liga MX | 2022/03/13 23:00 | Atletico San Luis v Puebla | W | 2-1 |
| Mexiko - Liga MX | 2022/03/03 03:00 | Atletico San Luis v Chivas Guadalajara | D | 2-2 |