[5] Cruz Azul 0-1 Atletico San Luis [10] 2022-04-24 22:00
Stadium: Estadio Azteca Round: 16
Referee: Jesus Rafael Lopez Valle Home Manager: Juan Reynoso Away Manager: Andre Jardine
Head to Head
| Mexiko - Liga MX | 2021/08/22 02:00 | Atletico San Luis v Cruz Azul | D | 0-0 |
| Mexiko - Liga MX | 2021/04/24 22:00 | Cruz Azul v Atletico San Luis | W | 3-2 |
| Mexiko - Liga MX | 2020/08/24 00:35 | Atletico San Luis v Cruz Azul | W | 1-3 |
| Mexiko - Liga MX | 2020/01/18 01:00 | Atletico San Luis v Cruz Azul | L | 2-1 |
| Mexiko - Liga MX | 2019/11/24 01:00 | Cruz Azul v Atletico San Luis | W | 3-1 |