[14] Louisville 34-17 Virgínia [13] 2022-10-08 16:00
Stadium: Scott Stadium Round: 1
Home Manager: Tony Elliott Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/10/09 19:00 | Virgínia v Louisville | L | 34-33 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virgínia | L | 17-31 |
| NCAAF | 2019/10/26 19:30 | Virgínia v Louisville | W | 21-28 |
| NCAAF | 2018/09/22 16:30 | Louisville v Virgínia | L | 3-27 |
| NCAAF | 2017/11/11 20:30 | Virgínia v Louisville | W | 21-38 |
| NCAAF | 2016/10/29 16:00 | Louisville v Virgínia | W | 32-25 |
| NCAAF | 2015/11/14 17:30 | Louisville v Virgínia | W | 38-31 |
| NCAAF | 2014/09/13 16:30 | Virgínia v Louisville | L | 23-21 |
Home History
| NCAAF | 2022/10/01 16:00 | Louisville v Boston College | L | 33-34 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAAF - Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
Away History
| NCAAF | 2022/10/01 23:30 | Virgínia v Duke | L | 17-38 |
| NCAAF | 2022/09/23 23:00 | Virgínia v Syracuse | L | 20-22 |
| NCAAF | 2022/09/17 18:00 | Old Dominion v Virgínia | W | 14-16 |
| NCAAF | 2022/09/10 20:00 | Virgínia v Illinois | L | 3-24 |
| NCAAF | 2022/09/03 16:30 | Richmond v Virgínia | W | 17-34 |
| NCAAF | 2021/11/27 20:45 | Virginia Tech v Virgínia | L | 29-24 |
| NCAAF | 2021/11/20 20:30 | Virgínia v Pittsburgh | L | 38-48 |
| NCAAF | 2021/11/14 00:30 | Notre Dame v Virgínia | L | 28-3 |