[14] Louisville 34-17 Virgínia [13] 2022-10-08 16:00
Stadium: Scott Stadium Round: 1
Home Manager: Tony Elliott Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/10/09 19:00 | Virgínia v Louisville | L | 34-33 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virgínia | L | 17-31 |
| NCAAF | 2019/10/26 19:30 | Virgínia v Louisville | W | 21-28 |
| NCAAF | 2018/09/22 16:30 | Louisville v Virgínia | L | 3-27 |
| NCAAF | 2017/11/11 20:30 | Virgínia v Louisville | W | 21-38 |
| NCAAF | 2016/10/29 16:00 | Louisville v Virgínia | W | 32-25 |
| NCAAF | 2015/11/14 17:30 | Louisville v Virgínia | W | 38-31 |
| NCAAF | 2014/09/13 16:30 | Virgínia v Louisville | L | 23-21 |